"The results may be important for further research into possible treatments to counteract the risk of people with type 2 diabetes being affected by Alzheimer's," says Olov Rolandsson, senior professor at the Department of Public Health and Clinical Medicine at Umeå University, research leader and first author of the study.
Caption: Professor Olov Rolandsson. Credit: Mattias Pettersson.
The substances that the researchers have studied are two so-called beta-amyloids, which are among the most important components of the plaques found in the brains of people with Alzheimer's disease.
The researchers measured the concentrations in the blood of the beta-amyloids Aβ1-40 and Aβ1-42 as well as the enzyme that breaks down the beta-amyloids in a test group with type 2 diabetes and in a healthy control group. The two groups were given infusion of glucose for four hours, which induced acute hyperglycaemia among the participants in both groups, i.e. high blood sugar levels, after which repeated samples were taken from the subjects.
Immediately after the infusion of the sugar solution, the groups had similar values. Soon, the values of beta-amyloids fell sharply in the control group, while the values of the amyloid-degrading enzyme rose. Among the group with type 2 diabetes, there were no changes, i.e. the levels of beta-amyloid did not decrease, nor was there be an increase in the enzyme that breaks down amyloid.
The results indicate that the body in people with type 2 diabetes do not have the same ability as healthy people to take care of beta-amyloid, which could increase the risk that it is then stored in the brain and causes cognitive diseases such as Alzheimer's.
"More research is needed to confirm the results of this limited study. Hopefully, in the long term, it can also lead to new treatments. But the findings underline the importance of preventing type 2 diabetes as far as possible and that people who do have it should avoid having episodes of high blood sugar," says Olov Rolandsson.
The study was conducted on ten people with type 2 diabetes and eleven people without diabetes in the control group. The participants were aged 66–72 years.
The study is published in the scientific journal Journal of Alzheimer's Disease.
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NOTES FOR EDITORS
CONTACT
Olov Rolandsson
Department of Public Health and Clinical Medicine, Umeå University
Phone: +46 90 785 35 71
Cell phone: +46 70 590 20 52
Email: olov.rolandsson@umu.se
ARTICLE
Acute Hyperglycemia Induced by Hyperglycemic Clamp Affects Plasma Amyloid-β in Type 2 Diabetes
Olov Rolandsson, Andreas Tornevi, Pär Steneberg, Helena Edlund, Tommy Olsson, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow
DOI: 10.3233/JAD-230628
ABOUT THE JOURNAL OF ALZHEIMER’S DISEASE (JAD)
The Journal of Alzheimer's Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment, and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. Groundbreaking research that has appeared in the journal includes novel therapeutic targets, mechanisms of disease, and clinical trial outcomes. JAD has a Journal Impact Factor of 3.4 according to Journal Citation Reports™ (Clarivate, 2024). The journal is published by IOS Press, now part of Sage. www.j-alz.com
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