The Fifth Conference of the International CoQ10 Association is a publication that focuses on new progress that has been made in elucidating the mechanisms by which CoQ10 exerts its benefits in cardiovascular disease, with new insights on the effects of this molecule on NO-dependent endothelial function and on extracellular SOD. Some more recent research fields have seen the involvement of CoQ10, such as the vast area of gene induction. There is also a new approach on the possible relationships between CoQ10 and the inflammatory response in cancer. Finally, the study of antioxidant properties of CoQ10 has been extended to encompass its protective effect against DNA damage.
This book contains peer-refereed original papers and reviews presented at the 5th conference of the International Coenzyme Q10 Association, held in Kobe, Japan, November 9–12, 2007. It covers many of the biochemical and biomedical issues currently explored in CoQ research throughout the world. The 50th anniversary of the discovery of CoQ10 was celebrated during the conference and therefore Dr. Fred Crane’s paper, who first isolated coenzyme Q10, opens this publication.
Some of the papers deal with the classical bio-energetic and antioxidant properties of coenzyme Q10, with special attention for the biomedical and clinical implications arising from these functions. Its antioxidant aspects are also deeply discussed in several papers. Some of these papers specifically deal with new fields where the antioxidant properties of coenzyme Q have been linked to measurable effects in dermatology and in the field of vascular dysfunction.
This book, which includes such a wide variety of articles dealing with CoQ10 involvement in many different fields, will interest many readers. Some of the biochemical data dealing with the basic aspects of coenzyme Q will hopefully lead to better understanding its clinical effects. On the other hand, some of the clinical data might shed a new light on CoQ10 properties.